Madhu Babu Battu

MADHU BABU BATTU Contact: -,-,- EDUCATION - Birla Institute of Technology and Science (BITS)-Pilani, Hyderabad, India, Division of Pharmaceutical sciences Ph.D. in Pharmacology/Neuropathic Pain Thesis Title: Design, Synthesis and Pharmacological Evaluation of Novel Cathepsin S Inhibitors- University of Hyderabad, Hyderabad, India Dr. Reddy's Institute of Life Sciences Internship, M.S (Pharm) Project- National Institute of Pharmaceutical Education & Research (NIPER)-Hajipur, India, M.S (Pharm) in Pharmacoinformatics Dissertation Title: Homology Modeling and Validation of Human Complement Receptors in Inflammation - Kakatiya University, Warangal, India Bachelor of Pharmacy National Tests Qualified 2009 CSIR-UGC NET (National Eligibility Test for JRF & LS) Qualified in Life Sciences stream. 2008 GATE (Graduate Aptitude Test in Engineering) Qualified in Pharmaceutical Sciences EXPERIANCE 2016-Present Current Position, National Post-Doctoral Fellow (individual project as Principal Investigator) Mentor: Dr. Sangita Mukhopdhyay, PhD. Center for DNA Fingerprinting and Diagnostics, Hyderabad Laboratory of Molecular Cell Biology. Currently working on screening and development of protein interaction inhibitors of PE/PPE family proteins as anti-virulent agents via suppression of pathogenic properties of Mycobacteria. Identification of components of the signaling pathways utilized in bacterial subversion of phagocytosis using molecular biology techniques. Development of Novel drug candidates against interactive complexes of PPE and host proteins using cell-based cytokine estimation assays. Discovery and development of Anti-inflammatory peptides (drug candidates) from bacterial source using chemical induced inflammatory mice models. - Industrial Research, Research Associate, Head of division: Dr. Sreedhara R. Voleti, PhD. Chemveda Life Sciences India Pvt Ltd., Hyderabad Drug Discovery Laboratory. Designed and developed small molecule dual inhibitors for PI3K and mTOR kinases for the treatment of various cancers by utilizing in silico docking studies, in vitro enzyme and cell-based cancer drug screening assays and in vivo toxicity studies. - Doctoral Research, Senior Research Fellow Supervisor: Prof. P. Yogeeswari, PhD. Birla Institute of Technology and Science, Department of Pharmacy,Pharmacy Research Group. Discovered and characterized novel Cathepsin S inhibitors for the treatment of Neuropathic pain. Examined potential neuroprotective and pain alleviating effects of promising novel drug candidates by analyzing behavioral animal models and molecular levels of inflammatory mediators by gene and protein expression studies and microscopic imaging studies. - Masters Project Internship Supervisor: Dr. Sreedhara R. Voleti, PhD, University of Hyderabad, Dr. Reddy's Institute of Life Sciences, Division of Computational Biology, utilized several bioinformatic tools for the structure development of GPCR complement receptors and designing of antagonistic drug scaffolds for the inflammatory diseases. SKILLS AND TECHNIQUES Expertise in handling of surgery based neuropathic pain animal models (CCI, PNL and STZ induced rat models), Formalin, carrageenan and collagen induced inflammatory mice models, Mouse Excisional Wound Model, MeHg & LPS induced neurodegenerative rat models. • Handling of various experimental Mouse and Rat models and drug administration by various routes. • Handling skills in mammalian cell culture maintenance and related cell-based assays. • Histopathological and molecular analysis of various in-vivo and ex-vivo tissue experimental samples. • Pharmacokinetic studies for drug candidates using liquid chromatography applications (HPLC). • Gene and Protein expression analysis using PCR amplification, gel electrophoresis, western blotting, gene cloning and recombinant protein purification. • Computer Aided Drug Designing Skills on Molecular Docking, Dynamics simulations, Homology modeling and 3D QSAR mapping. • (Softwares: Schrödinger (Maestro), Sybyl, AutoDock, Desmond, Modeller, Graphpad, R statistical tool) • Statistical analysis of the experimental data PUBLICATIONS • Rahila Qureshi, Nagender Rao Rameshwaram, Madhu Babu Battu, Sangita Mukhopadhyay. PPE65 of M. tuberculosis regulate pro-inflammatory signalling through LRR domains of Toll like receptor-2. Biochemical and Biophysical Research Communications. 2018 Nov 21. [Epub ahead of print] • Raghavendra G, Gajanan S. Inamdar, Omer Kuzu1, Saketh S. Dinavahi, Jacek Krzeminski, Madhu Babu Battu, Sreedhara R Voleti, Shantu Amin, Gavin P. Robertson. Identifying the structure activity relationship of leelamine necessary for inhibiting intracellular cholesterol transport. Oncotarget, 2017, 25(17),-. • Hasitha Shilpa Anantaraju, Madhu Babu Battu, Srikant Viswanadha, Dharmarajan Srirama, Perumal Yogeeswari; Cathepsin D inhibitors as potential therapeutics for breast cancer treatment: Molecular docking and bioevaluation against triple negative and triple positive breast cancers, Molecular Diversity, 2016, 20(2), 521-35. • Neerja Kaushik-Basu, Patrisha Joseph Theresa, Dinesh Manvar, Sridevi Kondepudi, Madhu Babu Battu, Dharmarajan Sriram, Amartya Basu, Perumal Yogeeswari, Multiple e-Pharmacophore Modeling, 3DQSAR and High-Throughput Virtual Screening of Hepatitis C virus NS5B Polymerase Inhibitors. Journal of Chemical Information and Modeling, 2014, 54(2), 539-52. • Madhu Babu Battu, Anchuri Madhuri Chandra, Dharmarajan Sriram, Perumal Yogeeswari, Pharmacophore-Based 3D QSAR and Molecular Docking Studies to Identify New Non-Peptidic Inhibitors of Cathepsin S, Current Medicinal Chemistry, 2013, 21(16),1910-21. • Venkat Koushik Pulla, Madhu Babu Battu, Mallika Alvala, Dharmarajan Sriram, Perumal Yogeeswari, Can targeting SIRT-1 to treat type 2 diabetes be a good strategy? A review, Expert opinion on therapeutic targets. 2012, 16(8):819-32. PATENTS • Perumal Yogeeswari, Dharmarajan Sriram, Madhu Babu Battu, Brahmam Medapi, Indian patent application on “A compound for treating inflammatory neuropathic pain and cancer”. Patent application no. 2945/DEL/2014 dated 15/10/2014. POSTER PRESENTATIONS AND WORKSHOPS • Poster Presentation – European Federation of IASP Chapters (EFIC), October 2013, Florence, Italy. • Poster Presentation–3rd World congress on Biotechnology (September 2012), OMICS-Hyderabad. • Certificate of Training- Workshop on Recent advances in computational biology and structure-based drug designing. 2012, OMICS-Hyderabad. • Poster Presentation– CTPS 2012, BITS-Pilani, Hyderabad. • Workshop- Participation - workshop on recent advances in life science education & research, Dept. of. Pharmacology, NIPER-Hyderabad, September 2012. • Participation – International Seminar on Current Trends in Pharmaceutical Research: Focus on Orphan Diseases, January 2010, NIPER- Hajipur. • Participation– International Conference on chemoinformatics, chemogenomics and computational chemistry approaches in drug discovery. (August 2009)-IIITM-Trivandrum. TEACHING EXPERIENCE Assistant Professor in Department of Pharmacology, Max Institute of Pharmaceutical Sciences, Khammam, Telangana, India. (From 1/9/2010 to 4/8/2011). AWARDS • National Post-Doctoral Fellowship (N-PDF), DST-SERB, New Delhi, India, September-2016. • CSIR foreign travel award from CSIR-HRDG, New Delhi, for European Federation of IASP Chapters (EFIC) Pain conference, Florence, Italy 9th October 2013. • Awarded CSIR-Senior research fellowship from CSIR-HRDG, New Delhi, in March 2012. Individual research projects written and handled • Title: “Screening and Development of Protein Interaction Inhibitors of PE/PPE Family Proteins PPE2 and PPE18 as Anti-Tuberculosis Agents via Suppression of Pathogenic Properties of Mycobacteria”. Project sanctioned under scheme SERB-National Post-Doctoral Fellowship (N-PDF), DST, India. My role is Principal Investigator under mentorship of Dr. Sangita Mukhopadyay, CDFD, Hyderabad, New Delhi, India (Project number: PDF/2016/00074). Project started in September-2016 and currently working for the project. • Title: “Design, Synthesis and Pharmacological Evaluation of Novel Cathepsin S Inhibitors”. Project approved and sanctioned by CSIR- SRF scheme, New Delhi, India (project sanction number: 09/1026 (0006)/2012.EMR-I). My role is Senior research fellow under supervision of Dr. Yogeeswari, Pharmacy department, BITS-Pilani, Hyderabad. Project Started in March-2012, completed in June-2015 at BITSPilani, Hyderabad, India. REFERENCES Prof. P. Yogeeswari Department of Pharmacy Birla Institute of Technology and Science-Pilani, Hyderabad campus, Jawahar nagar, Shameerpet, R.R. District, Hyderabad. Telangana, India, 500078. Tel: --- Dr. Sreedhara R. Voleti Managing Director, INDRAS Pvt. Ltd. and Executive Director, Chemveda Life Sciences India Pvt Ltd. 8-2-703/A/B/V-29, C-10, Banjara View Apartments, Road No.12, Banjara Hills, Hyderabad Telangana, India, 500034. Mob: --- Dr. Sangita Mukhopadhyay Staff Scientist Laboratory of Molecular and Cellular Biology, Centre for DNA Fingerprinting and Diagnostics (CDFD), Inner Ring Road, Uppal, Hyderabad, Telangana, India, 500 039. Tel: -,--