Dr. Geethalakshmi Radhakrishnan – Senior Manager
Location: Bangalore
E- Mail ID:-Mobile No:-
Professional Profile
A highly experienced & motivated Project Manager with a successful track record of driving multiple projects in demanding Techno commercial environments, across a wide range of industries such as Biotechnology & Pharmaceuticals. Experienced both in vitro molecular biology techniques as well as various animal disease models, published few scientific papers (Total Impact factor- 23.8) with international work experience in JAPAN for 4.5 years, Presented scientific data at 9 international conferences. 5 years of product management experience in delivering successful outcomes within Stem cells processing and banking division. 5 years of project management experience covering Active pharmaceutical ingredients development and Formulations technology transfer from Japan to India. Possessing extensive expertise on the full project cycle from scale up trials until commercial production.
Core Skills
Project management & Technology transfer
Risk assessment & Quality Management System
Scientific writing
Publication experience as first author on papers published in medical journals
Attention to detail & Superior English- language skills
Knowledge of Biostatistics
Literature reviewing and evaluation capabilities
Ability to multi-task and work under tight timelines
Lifesciences industry experience
Pharmaceutical industry experience
Eagerness to learn
In vivo & In vitro experiments in Biomedical sciences
Proactive & efficient communication
Career Summary
(I) Medreich Limited:
Senior Manager (5th Jan 2017 ~Till Date)
Spear headed project management best practices as per ISPE guidelines. Leads team of 10 members in defining project strategies, Defined clear targets and objectives and communicated to all stakeholders involved and ensures project scope is defined & controlled. Anticipates potential conflict situations for proactive solutions and manages conflicts situations to result in win - win outcomes.
Key achievements include Technology transfer of Generic formulation products (Totally 15 products till date & 10 products are in pipeline) from Japan to India. Out of 15 products 9 products have been commercialized till date
(II) Strides Shasun Limited.
Senior Manager (Business Development) 11th Dec 2014 ~31st Dec 2016
Thorough knowledge in the API manufacturing plants & resolving technical queries, executing customer audits in manufacturing plants, exposure in formulation industry.
Business Development activities. Handled 4 commercial Generic API products business for Japan market. Extensively worked on new API development projects in India for Japan market. Sales & Marketing of API to APAC region. Achieved financial targets of 10 Mn USD annually. Forecasting & order fulfillment.
(III) Life cell International Pvt. Ltd., Chennai, India 5th April 2010 ~ 10th Dec 2014
Scientist (R & D) 5th April 2010 ~ Apr 2011
Product manager April 2011 ~ June 2013
Senior Manager (July 2013 ~ 10th Dec 2014)
Accomplished Dental pulp stem cells isolation & expansion project from Dental pulp tissues as a Product manager during Technology transfer phase from France to India.
Upstream and downstream processing of cell lines
Successfully completed more than 1000 Dental pulp tissue samples cultivation and production, isolation, purification, Analytical characterization & cryopreservation.
Headed Technical queries team and involved in Internal quality management and supervised clean rooms as per ISO Class 7 & 8.
(IV) Dept. of Cardiovascular surgery, Faculty of Medicine, Kochi University, Kochi, Japan
Teaching Assistant (Part time), April 2006~March 2010
Research Assistant (Part time), April 2006~ March 2010
Cell line creation including Human umbilical vein endothelial cells, Rabbit aortic smooth muscle cells, CHO cells line handling.
Nf kappa B Phosphorylation studies by Western blot and Spectrophotometry.
Handling of primary and secondary antibodies in western blot, ELISA, flow cytometry.
Isolation and purification of proteins, enzymes by techniques such as Filtration, centrifugation, Chromatography, extraction, high affinity adsorption, Ultrafiltration techniques to purify the protein/enzymes.
Use of a hemocytometer, Handled HEP-G2 cells for monitoring cholesterol synthesis by analyzing HMG-CoA molecule.
Western blot analysis: Gel preparation, Protein isolation (cytoplasmic and nuclear), Determining the concentration of protein by standard curve generation, separation by SDS-PAGE, ELISA, immunoassays, spectrophotometry, enzyme assays.
(V) Christian Medical College & Hospital, Dept. of Dental & Oral Surgery, Vellore, India
Honorary Senior House Officer (Aug 2003-Feb 2004)
Education
PhD in Bio-Medical sciences, Faculty of Medicine, Kochi University, Kochi, Japan (April 2006 ~ March 2010.
Bachelor of Dental Surgery (BDS), Dr. MGR Medical University, Chennai, India.
Higher Secondary Education, Little Flower Convent Girls’ Higher Secondary School, Ranipet, India
Honors/Awards
Japanese Government Scholarship (Monbukagakusho: Mext), 2007 to 2010
“Best Presentee of the year”, Faculty of medicine, Kochi University, Feb, 2009.
National Merit Scholarship from Government of India,-.
Attended Group Study Exchange Programme organized by Rotary at Chicago, IL 2013.
Awarded the best practice of MEIJI way organized by Meiji, Japan, 2019.
Research skills
In vivo
Accomplished experiments in the discipline of Cardiovascular surgery such as “Balloon Injury Model” to simulate atherosclerosis in common carotid artery of rabbits.
Cardiac Transplantation experiments & Myocardial ischemic reperfusion injury model in rats.
Experienced in handling of laboratory animals such as Gastrostomy tube feeding in rabbits & mice. Collection of venous blood by cardiac puncture from rabbits & from tail vein of rats, mice etc. Drug injection through IV, IM, IP routes. Body weight and feed consumption recording. Urine collection and analysis. Anesthesia and euthanasia of animals. Animal dissection and organ collection.
In vitro
Tissue fixation, sectioning of OCT compound embedded tissue, parafilm fixed tissue.
Immunohistochemistry, Double Fluorescence immunostaining, Flow cytometry.
BIACORE analysis applying surface plasmon resonance phenomenon to analyze protein-protein interactions followed by analyte recovery.
Experience in isolation & handling of platelets and platelet aggregation assays.
Performing HPLC analysis & analyzing the data & reporting.
Software skills
Proficiency in NIH Image analysis and J Image analysis.
Working knowledge in SUFALAM, AXAPTA & SAP software.
Working knowledge of Operating system windows, Microsoft word, Adobe photoshop.
Language skills
Tamil- Native, English-Fluent, Hindi – Fluent (Passed Praveen Uttarardh Examination).
Japanese – Fluent, Japanese Language Proficiency Test - Level 3, 2009.
Training & Seminar
Undergone training on Japan work culture, 2018.
Undergone training in Aseptic tissue culture practices, Paal Biosciences, Bangalore, 2014.
Participated in the Indo Japan Symposium in the regulatory aspect of pharmaceutical industry.
Undergone training for RT-PCR applications, Applied Biosystems, Gurgaon, Delhi, May, 2011.
Attended Adventures in Attitude training, Lifecell International, Chennai, April, 2011.
Undergone training in BIACORE 3000 Analyte Recovery process, 2008
List of Conferences
S. No
Title
Session
Year
Conference
Country
1
A novel cholesterol lowering effect of dissolved organic matter from sea water in hyperlipidemic rabbits.
Poster
Oct,2007
XVI International Symposium
New York, USA.
2
Anti-atherosclerotic effect in dissolved organic matter of deep seawater.
Oral
Oct, 2008
American College of Surgeons 94th Annual Clinical Congress,
San Francisco, USA,
3
Studies on Possible Role of Anti-oxidant MCI-186 in Preventing Atherosclerosis through NF-κB Pathway.
Poster
Mar, 2006
70th Japanese Circulation Society,
Nagoya, Japan.
4
Inhibition of Atherosclerosis Development by MCI-186 is Correlated with Downregulation of ASK-1 and NF-κB Pathway
Oral
Nov, 2006
Free Radical Conference
Osaka, Japan
5
Inhibition of Neointimal hyperplasia by MCI-186 is correlated with Downregulation of ASK-1 and NF-κB Pathway
Oral
Apr, 2007
Japanese Surgical Society
Osaka, Japan
6
-Participated-
-
Nov, 2007
Free Radical Conference
Osaka, Japan
7
Anti-atherosclerotic effect of Dissolved Organic Matter from Sea Water
Digital Poster
May 2008
Japanese Surgical Society
Nagasaki, Japan
8
-Participated-
-
Nov, 2008
Free Radical Conference
Tokyo, Japan
9
Participated
Stall
April 2015
CPhI, Japan
Tokyo Japan
10
Participated
Stall
April 2016
CPhI, Japan
Tokyo Japan
11
Presented on Kaizen meeting
Oral
Feb 2017
Kaizen conference, Meiji
Tokyo, Japan
Journal Publications
S. No
Title
Name of the journal
Impact factor
No. of citations
1
Geethalakshmi Radhakrishnan, S. Sasaguri. Inhibition of neointimal hyperplasia development by MCI-186 is correlated with downregulation of NF-κB pathway.
Circulation Journal
Vol, 72, May-
Geethalakshmi Radhakrishnan, S. Sasaguri. Intake of dissolved organic matter from deep seawater inhibits atherosclerosis progression.
BBRC,
Vol. 387, Issue 1, 11, pp 25-30, Sep-
M. Yamamoto, Geethalakshmi Radhakrishnan, S. Sasaguri. Bilirubin oxidation provoked by nitric oxide radicals predicts the progression of acute cardiac allograft rejection.
Am. J. Transplant. 2007 Aug; 7(8):-.
6.048
1
4
N. Hirose, Geethalakshmi Radhakrishnan, S. Sasaguri. The local injection of peritoneal macrophages induces neovascularization in rat ischemic hind limb muscles.
Cell Transplantation, Vol.17, pp. 211-222,-
M. Yamamoto, Geethalakshmi Radhakrishnan, S. Sasaguri. Biphasic elevation of bilirubin oxidation during myocardial ischemia reperfusion.
Circulation Journal Vol.72, No 9, pp. - Sep-
W. Seichiro, Geethalakshmi Radhakrishnan, S.Sasaguri. Postoperative administration of landiolol hydrochloride for patients with supraventricular arrhythmia: the efficacy of sustained intravenous infusion at a low dose.
Interact Cardiovasc Thorasic surg.
2009 Nov; 9(5):-
Book Publications
1. Geethalakshmi Radhakrishnan, Shiro Sasaguri. Deep seawater: A boon to cardiovascular disease prone individuals in a book entitled Seawater by NOVA PUBLISHERS in 2009.
Reference
1. Prof. Shiro Sasaguri, MD, PHD
Director of Tokyo Hospital,
Tokyoto, Nakanoku egota 3-15-2; 〒-
Email ID-- Mobile No-
