Ana Paula Miranda Mendonça

Ana Paula Miranda Mendonça R. Prof. Rodolpho Paulo Rocco, 373 Cidade Universitária, Rio de Janeiro - RJ,- Phone: - • Email:-Current position 06.2018 – 06.2019 Federal University of Rio de Janeiro, Rio de Janeiro, Brazil Ph.D. in Biochemistry Supervisor: Prof. Marcus Oliveira Dissertation: The mitochondria as protagonist: how the energy metabolism is altered under nutritional, redox and behavioral stresses. Grant of National Council for Scientific and Technological Development (CNPq) Education 06.2015 - 06.2019 Federal University of Rio de Janeiro, Rio de Janeiro, Brazil Ph.D. in Biochemistry Supervisor: Prof. Marcus Oliveira Dissertation: The mitochondria as protagonist: how the energy metabolism is altered under nutritional, redox and behavioral stresses. Grant of National Council for Scientific and Technological Development (CNPq) 05.2013 - 05.2015 Federal University of Rio de Janeiro, Rio de Janeiro, Brazil Msc. in Biochemistry Supervisor: Prof. Marcus Oliveira Project: Effect of iron on the energy metabolism and redox of neuroblastomas and glioblastomas cell lines. Grant of Coordination of Improvement of Higher Level Personnel (CAPES) 03.2009 - 05.2013 Federal University of Rio de Janeiro, Rio de Janeiro, Diploma in Biological Sciences Medical Modality Grants 04.2018 – 03.2019 Bi-nationally Supervised Doctoral Degrees German Academic Exchange Service (DAAD) Research experience- Universität Bremen, Bremen, Germany Project: Effects of chronic fructose exposure on the energy metabolism of primary astrocytes. Advisor: Prof. Marcus Oliveira and Prof. Ralf Dringen • Analyzing the effects of chronic fructose exposure in energy metabolism using primary astrocytes as an experimental model. 2013 - 2018 Federal University of Rio de Janeiro, Rio de Janeiro, Brazil Project: Effect of iron on the energy metabolism and redox of neuroblastomas and glioblastomas cell lines. Advisor: Prof. Marcus Oliveira • Highlighted how mitochondrial functionality is altered in a stress environment mediated by iron as the effects of this transition metal in neuro and glioblastomas cell lines. Ana Paula Mendonça, pg1 • Under revision for submission. 2015 - 2017 Federal University of Rio de Janeiro, Rio de Janeiro, Brazil Project: Highly aggressive behavior induced by social stress is associated to reduced cytochrome c oxidase activity in mice brain cortex Advisor: Prof. Marcus Oliveira and Dr. Viviane Fragoso • Investigating the metabolic basis of aggressive behavior in a mice model. • Published on Neurochemistry International, March 2019. Laboratory techniques • • • • • High resolution respirometry (Oroboros instruments and Hansatech) Cell & tissue culture techniques SDS-PAGE Western blot Enzyme activity • • • Confocal laser fluorescence microscopy for mitochondria structure and potential Lactate and glucose/fructose homeostasis Basics culture techniques for D. melanogaster Linguistic proficiency ● Portuguese: Native ● English: skills for speech, writing and listen (level C2) ● Spanish: skills for speech, writing and listen (level B1) ● ● French: skills for speech and listen (level B1) German: skills for speech and listen (level A2) Digital skills • MS Office (Word, PowerPoint, Excel, Outlook); • Image editing (Adobe Lightroom and Adobe Photoshop) • Graphics (GraphPad Prism, Sigma Plot) Conference Presentations Oral • • X Mitomeeting, Guapé, Minas Gerais: Metabolic changes in CNS tumor cells induced by iron. Mendonça, AP; Rodrigues, M; Amoedo, N; Rumjanek, F; Oliveira, MF, 2017. O2k-Workshop on High-Resolution Respirometry, Schröcken, Austria: Effect of Iron on Energy Metabolism and Redox Tumor Cells of the Central Nervous System. Mendonça, AP; Rodrigues, M; Amoedo, N; Rumjanek, F; Oliveira, MF, 2014 Poster • European Bioenergetics Conference – EBEC, Riva del Garda, Italy: Effects of iron on mitochondrial function and redox metabolism of central nervous system cell lines. Mendonça, AP; Rodrigues, M; Amoedo, N; Rumjanek, F; Oliveira, MF, 2016 • IBRO - 9th World Congress International Brain Research Organization. Rio de Janeiro, Brazil. Effects of exposure on mitochondrial iron metabolism and redox tumor cells of the central nervous system. Mendonça, AP; Rodrigues, M; Amoedo, N; Rumjanek, F; Oliveira, MF, 2015. Ana Paula Mendonça, pg2 Publications 1. Mendonça APM, Hoppe LY, Gaviraghi A, Araújo-Jorge TC, de Oliveira GM, Felippe RM, Oliveira MF*, da Silva Fragoso VM*. Highly aggressive behavior induced by social stress is associated to reduced cytochrome c oxidase activity in mice brain cortex. Neurochem Int. v. 126, p.210 - link 2. Lima JPM, Rayêe, Silva-Rodrigues T, Pereira PRP, Mendonça APM, Rodrigues-Ferreira C, Szczupak D, Fonseca A, Oliveira MF, Lima FRS, Lent R, Galina A, Uziel D*. Perinatal Asphyxia and Brain Development: Mitochondrial Damage Without Anatomical or Cellular Losses. MOLECULAR NEUROBIOLOGY, v. 55, p. 112, 2018. link 3. Nogueira NP, Saraiva FMS, Oliveira MP, Mendonça APM, Inacio JDF, Almeida-Amaral EE, Menna-Barreto RF, Laranja GAT, Torres EJL, Oliveira MF, Paes MC*. Heme modulates Trypanosoma cruzi bioenergetics inducing mitochondrial ROS production. FREE RADICAL BIOLOGY AND MEDICINE, v. 108, p. 183-191, 2017. link Ana Paula Mendonça, pg3