Tese Peter

Ni t r of ur ant oi n. A.ANTI BACTERI ALACTI VI TY: Thedr ug‘ Ni t r of ur ant oi n’ i sadr ugt hati scommonl yusedf ort r eat i ngur i nar y t r acti nf ect i ons( usual l yuncompl i cat edones)becauseofi t sf eat ur es i ncl udi ngt oxi ci t y , i t sabi l i t yt oi nhi bi torki l lmi cr oor gani sms( ant i mi cr obi al spect r um)andi t sbact er i alr esi st ance.Ii sr esi st antagai nstbact er i asuchas E.Col iandEnt er ococci . I ti sconv er t edbybact er i alni t r or educt asest oel ect r ophi l i ci nt er medi at es whi chi nhi bi t st heci t r i caci dcy cl easwel last hesy nt hesi sofDNA, RNAand Pr ot ei n.I t sant i bact er i alact i v i t yi shi gheri naci di cur i neasi ti smor e bact er i ci dal( ki l l sbact er i a)i nhi gherur i neaci di t yconcent r at i on( about 100ug/ ml )whi l ei nl oweraci di t yconcent r at i on, i ti sbact er i ost at i c( bact er i a i nhi bi t i ng) . B.MECHANI SM OFACTI ON: Whent heNi t r of ur ant oi ni sconv er t edt oi t si nt er medi at esi tbecomeshi ghl y r eact i v eorhy perr eact i v ewhi chdamagest heDNA.I tki l l st hebact er i aby ent er i ngi nt ot hei rcel landdamagest hegenet i cmat er i almaki ngi tunabl et o r epai rormul t i pl yhencest oppi ngt hei nf ect i on. C.PHARMACOKI NETI CS: Ni t r of ur ant oi ni sadmi ni st er edor al l yandi sabsor bedt hr ought heGI Ti na r api dmot i onandi sexcr et edpr edomi nant l yt hr ought heur i newi t h25%ofi t unchangedaf t eri thasgonet hr oughGI Tenzy meswhi chcausest hebr own col or at i onoft heur i ne. Thepl asmaconcent r at i ont hedr ugi snoti ncr easedt ot her apeut i cl ev el becauset hedr ugi sr api dl yabsor bedandt henel i mi nat ed. D.ADVERSEEFFECTS: Theymayi ncl ude: -Headache -Di zzi ness -Nausea -Di ar r hea/Bl oodySt ool -Vomi t i ng -ChestPai n -Dr yCough -Fev er -Demy el i nat i on -Acut ePneumoni t i s -Li v erpr obl ems( I t chi ng, Lossofappet i t e, Dar kUr i ne) -Hemol y t i cAnemi a -Numbnessi nhandsandf eet -Ti r edness -Pal eness