Khalil Ahmad

STATISTICAL ANALYSIS REPORT (SAR) Prepared by Khalil Ahmad, Senior Biostatistician Statistical Analysis We used descriptive and analytic statistics using Statistical Package for the Social Sciences SPSS 26 (SPSS, Chicago, IL, USA). Summarized data was presented as mean ± standard deviation for the quantitative and n (%) for the qualitative features. The two-sample t-tests were applied to test the significant difference between two groups; bilateral and unilateral, discharge on same day and after same day. The Chi-square (χ2) tests were implemented to test the association between the RIRS and discharge on same day with other qualitative features at 5% level of significance. The results were evaluated against a confidence interval of 95% and a p-value < 0.05 for statistical significance. Results Table 1. Descriptive Statistics Features Age Serum creatinine Size right (Median) Size left (Median) HU right HU left Duration of jj stent in days Duration of operation minutes Size right Size left BMI Time b/w operation and discharge in hrs Mean ± SD 38.80 ±- ±- ±- ±- ±- ±- ± 2.06 1.27 ±- ±- ± 9.05 Table 2. Testing of mean difference of quantitative factors against Stone Free Stone Free Age Serum creatinine Size right Size left HU right HU left Duration of jj stent in days Duration of operation minutes N Stone free Not free Stone free Not free Stone free Not free Stone free Not free Stone free Not free Stone free Not free Stone free Not free Stone free Not free - Mean SD - - p-value- Size right Size left BMI Time between operation and discharge in hours Stone free Not free Stone free Not free Stone free Not free Stone free Not free - - - - Table 3. Testing of mean difference of quantitative factors against Complications Late Complications Late Age Serum creatinine Size right Size left HU right HU left Duration of jj stent in days Duration of operation minutes Size right Size left BMI Time (in hours) between operation and discharge Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No N- Mean- SD- p-value- Sudanese 1% Turkish Nationality 1% Yemeni Sirlankan 6% 4% American 1% Qatri 5% Filpino 5% Palestinian 2% Pakistani 10% Indian 27% Nepalese 26% Table 4. Demographics of Patients Features Comorbidities No Yes Complain positions Bilateral Right Left History of stone disease Yes No Surgical history Yes No Urine culture Positive Negative Site right 1 Lower calyx Middle calyx Egyptian 5% n % p-value 47 35 57.3 42.7 38 24 20 - 46 36 56.1 43.9 0.116 43 39 52.4 47.6 0.532 1 81 1.2 98.8 0.000 29 10 35.8 12.3 0.058 Bangladeshi 7% Upper calyx Renal pelvis Proximal ureter PUJ Site right 2 Lower calyx Middle calyx Upper calyx Site right 3 Lower calyx No. of Stones/Right Single Multiple Site left 1 Lower calyx Middle calyx Upper calyx Renal pelvis Proximal ureter PUJ Site left 2 Lower calyx Middle calyx Upper calyx Renal pelvis Proximal ureter Site left 3 Lower calyx No. of Stones/Left Single Multiple Dilatation Right No Yes Dilatation Left No Yes Pre-operative stenting No Yes Starting site Right Left Type of anesthesia General Spinal Rigid ureteroscopy Yes No Sheath size 10/12 11/13 12/14 Type of flexible ureteroscopy Innovex OTU PUSEN Storz flex Type of laser Homium laser Thulium laser Not mention type of flaz Size of laser fiber 150um 200um 400um 19 19 1 3 - 12 8 2 - 5 100.0 49 32 60.5 39.5 - - 8 6 2 1 1 - 6 100.0 49 32 60.5 39.5 0.007 31 51 37.8 62.2 0.001 31 51 37.8 62.2 0.001 26 56 31.7 68.3 0.000 50 32 61.0 39.0 0.001 77 5 93.9 6.1 0.000 78 4 95.1 4.9 0.000 29 30 6 - 1 37 2 3 - 38 32 10 - 1 49 3 - 0.007 Not mention type of fibers Stone dusting Yes No Stone fragmentation Yes No Popcorn lithotripsy Yes No Total Dormiaused Yes No Type of jj stent With thread Without thread Complication early Yes No Complications Late Yes No Type of admission Daycare In patient admission Radiology follow up CT US XRAY Post-operative Stone status Stone free Not free Right residual diameter- Left residual diameter- Second look operation Yes No Number of procedures to stone free 1 2 Blood thinners Yes No Discharge on same day No Yes ER Visits No Yes Complains 1 No complains 29 35.4 75 7 91.5 8.5 0.000 45 37 54.9 45.1 0.209 37 45 82 - 0.209 56 26 68.3 31.7 0.000 50 32 61.0 39.0 0.004 4 78 4.9 95.1 0.000 9 73 11 89 0.000 81 1 98.8 1.2 0.000 52 16 8 - 57 20 74.0 26.0 - - - - 13 69 15.9 84.1 0.000 71 10 87.7 12.3 0.000 1 81 1.2 98.8 0.000 4 78 4.9 95.1 0.000 73 9 89.0 11.0 0.000 73 89.0 0.000 0.000 Pain Complains 2 No complains Hematuria Complains 3 No complains Fever Complains 4 No complains LUTS Plan Discharged Admitted 9 11.0 78 4 95.1 4.9 0.000 81 1 98.8 1.2 0.000 79 3 96.3 3.7 0.000 81 1 98.8 1.2 0.000 Table 5. Testing the significance of associations of Strone free with other features Free Comorbidities No Yes Complain positions Bilateral Right Left History of stone disease Yes No Surgical history Yes No Urine culture Positive Negative No. of Stones/Right Single Multiple No. of Stones/Left Single Multiple Dilatation Right No Yes Dilatation Left No Yes Pre operative stenting No Yes Starting site Right Left Type of anesthesia General Spinal Rigid ureteroscopy Yes No Stone Free Not free p-value 34 (59.6%) 23 (40.4%) 12 (60.0%) 8 (40.0%) 0.978 30 (52.6%) 15 (26.3%) 12 (21.1%) 7 (35.0%) 6 (30.0%) 7 (35.0%) 0.333 29 (50.9%) 28 (49.1%) 13 (65.0%) 7 (35.0%) 0.275 28 (49.1%) 29 (50.9%) 10 (50.0%) 10 (50.0%) 0.946 1 (1.8%) 56 (98.2%) 0 (0.0%) 20 (100.0%) 0.551 34 (60.7%) 22 (39.3%) 11 (55.0%) 9 (45.0%) 0.655 31 (55.4%) 25 (44.6%) 14 (70.0%) 6 (30.0%) 0.253 23 (40.4%) 34 (59.6%) 7 (35.0%) 13 (65.0%) 0.673 25 (43.9%) 32 (56.1%) 6 (30.0%) 14 (70.0%) 0.277 22 (38.6%) 35 (61.4%) 4 (20.0%) 16 (80.0%) 0.130 34 (59.6%) 23 (40.4%) 13 (65.0%) 7 (35.0%) 0.673 53 (93.0%) 4 (7.0%) 19 (95.0%) 1 (5.0%) 0.753 54 (94.7%) 3 (5.3%) 19 (95.0%) 1 (5.0%) 0.964 Sheath size 10/12 11/13 12/14 Type of flexible ureteroscopy Innovex OTU PUSEN Storz flex Type of laser Homium laser Thulium laser Not mention type of flaz Size of laser fiber 150um 200um 400um Not mention type of fibers Stone dusting Yes No Stone fragmentation Yes No Popcorn lithotripsy Yes No Dormiaused Yes No Complication early Yes No Type of admission Daycare In patient admission Radiology follow up CT US XRAY Right residual diameter- Left residual diameter- Second look operation 19 (40.4%) 24 (51.1%) 4 (8.5%) 8 (53.3%) 5 (33.3%) 2 (13.3%) 0.479 1 (2.9%) 33(94.3%) 0 (0.0%) 1 (2.9%) 0 (0.0%) 3 (42.9%) 2 (28.6%) 2 (28.6%) 0.001 23 (41.8%) 26 (47.3%) 6 (10.9%) 12 (60.0%) 5 (25.0%) 3 (15.0%) 0.223 1 (1.8%) 39 (68.4%) 0 (0.0%) 17 (29.8%) 0 (0.0%) 8 (40.0%) 2 (10.0%) 10 (50.0%) 0.021 53 (93.0%) 4 (7.0%) 19 (95.0%) 1 (5.0%) 0.753 27 (47.4%) 30 (52.6%) 14 (70.0%) 6 (30.0%) 0.081 29 (50.9%) 28 (49.1%) 5 (25.0%) 15 (75.0%) 0.045 44 (77.2%) 13 (22.8%) 10 (50.0%) 10 (50.0%) 0.022 3 (5.3%) 54 (94.7%) 1 (5.0%) 19 (95.0%) 0.964 56 (98.2%) 1 (1.8%) 20 (100.0%) 0 (0.0%) 0.551 44 (77.2%) 10 (17.5%) 3 (5.3%) 8 (42.1%) 6 (31.6%) 5 (26.3%) 0.007 16 (55.2%) 1 (3.4%) 7 (24.1%) 5 (17.2%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (7.1%) 0 (0.0%) 1 (7.1%) 2 (14.3%) 6 (42.9%) 2 (14.3%) 1 (7.1%) 1 (7.1%) 0.000 16 (53.3%) 7 (23.3%) 6 (20.0%) 1 (3.3%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 1 (7.7%) 2 (15.4%) 8 (61.5%) 1 (7.7%) 1 (7.7%) 0.000 Yes No Discharge on same day No Yes ER Visits No Yes Complains 1 No complains Pain Complains 2 No complains Hematuria Complains 3 No complains Fever Complains 4 No complains LUTS Plan Discharged Admitted 9 (15.8%) 48 (84.2%) 4 (20.0%) 16 (80.0%) 0.665 3 (5.3%) 54 (94.7%) 1 (5.0%) 19 (95.0%) 0.964 51 (89.5%) 6 (10.5%) 17 (85.0%) 3 (15.0%) 0.592 51 (89.5%) 6 (10.5%) 17 (85.0%) 3 (15.0%) 0.592 55 (96.5%) 2 (3.5%) 18 (90.0%) 2 (10.0%) 0.260 56 (98.2%) 1 (1.8%) 20 (100.0%) 0 (0.0%) 0.551 56 (98.2%) 1 (1.8%) 18 (90.0%) 2 (10.0%) 0.101 56 (98.2%) 1 (1.8%) 20 (100.0%) 0 (0.0%) 0.551 Table 6. Logistic Regression Analysis of Stone Free 95% C.I. for OR Variables Duration of operation (min) B S.E. Wald p-value OR Lower Upper 0.017 0.009 4.157 0.041 1.018 1.001 1.035 Popcornlithotrips (1) -1.182 0.622 3.609 0.047 0.307 0.091 1.038 Dormiaused (1) -1.273 0.588 4.692 0.030 0.280 0.088 0.886 Constant -1.718 1.040 2.727 0.099 0.179 Table 6. Testing the significance of associations of Complication Late with other features Features Comorbidities No Yes Complain positions Bilateral Right Left History of stone disease Yes No Surgical history Yes No Urine culture Positive Complications Late Yes No p-value 6 (66.7%) 3 (33.3%) 41 (56.2%) 32 (43.8%) 0.548 5 (55.6%) 2 (22.2%) 2 (22.2%) 33 (45.2%) 22 (30.1%) 18 (24.7%) 0.829 3 (33.3%) 6 (66.7%) 43 (58.9%) 30 (41.1%) 0.145 3 (33.3%) 6 (66.7%) 40 (54.8%) 33 (45.2%) 0.224 0 (0.0%) 1 (1.4%) 0.724 Negative No. of Stones/Right Single Multiple No. of Stones/Left Single Multiple Dilatation Right No Yes Dilatation Left No Yes Pre operative stenting No Yes Starting site Right Left Type of anesthesia General Spinal Rigid ureteroscopy Yes No Sheath size 10/12 11/13 12/14 Type of flexible ureteroscopy Innovex OTU PUSEN Storz flex Type of laser Homium laser Thulium laser Not mention type of flaz Size of laser fiber 150um 200um 400um Not mention type of fibers Stone dusting Yes No Stone fragmentation Yes No Popcorn lithotripsy Yes No Dormiaused Yes No Complication early Yes 9 (100.0%) 72 (98.6%) 6 (66.7%) 3 (33.3%) 43 (59.7%) 29 (40.3%) 0.688 4 (44.4%) 5 (55.6%) 45 (62.5%) 27 (37.5%) 0.296 4 (44.4%) 5 (55.6%) 27 (37.0%) 46 (63.0%) 0.663 3 (33.3%) 6 (66.7%) 28 (38.4%) 45 (61.6%) 0.769 3 (33.3%) 6 (66.7%) 23 (31.5%) 50 (68.5%) 0.912 6 (66.7%) 3 (33.3%) 44 (60.3%) 29 (39.7%) 0.711 7 (77.8%) 2 (22.2%) 70 (95.9%) 3 (4.1%) 0.032 8 (88.9%) 1 (11.1%) 70 (95.9%) 3 (4.1%) 0.358 3 (37.5%) 4 (50.0%) 1 (12.5%) 26 (45.6%) 26 (45.6%) 5 (8.8%) 0.888 0 (0.0%) 5 (71.4%) 1 (14.3%) 1 (14.3%) 1 (2.8%) 32 (88.9%) 1 (2.8%) 2 (5.6%) 4 (44.4%) 4 (44.4%) 1 (11.1%) 34 (47.9%) 28 (39.4%) 9 (12.7%) 0 (0.0%) 6 (66.7%) 0 (0.0%) 3 (33.3%) 1 (1.4%) 43 (58.9%) 3 (4.1%) 26 (35.6%) 6 (66.7%) 3 (33.3%) 69 (94.5%) 4 (5.5%) 0.005 4 (44.4%) 5 (55.6%) 41 (56.2%) 32 (43.8%) 0.505 4 (44.4%) 5 (55.6%) 33 (45.2%) 40 (54.8%) 0.965 7 (77.8%) 2 (22.2%) 49 (67.1%) 24 (32.9%) 0.517 1 (11.1%) 3 (4.1%) 0.358 0.438 0.958 0.900 No Type of admission Daycare In patient admission Radiology follow up CT US XRAY Right residual diameter- Left residual diameter- Second look operation Yes No Discharge on same day No Yes ER Visits No Yes Complains 1 No complains Pain Complains 2 No complains Hematuria Complains 3 No complains Fever Complains 4 No complains LUTS Plan Discharged Admitted Stone Free Free Not free 8 (88.9%) 70 (95.9%) 9 (100.0%) 0 (0.0%) 72 (98.6%) 1 (1.4%) 0.724 7 (77.8%) 0 (0.0%) 2 (22.2%) 45 (67.2%) 16 (23.9%) 6 (9.0%) 0.165 3 (42.9%) 0 (0.0%) 1 (14.3%) 1 (14.3%) 2 (28.6%) 0 (0.0%) 0 (0.0%) 0 (0.0%) 14 (38.9%) 1 (2.8%) 7 (19.4%) 6 (16.7%) 4 (11.1%) 2 (5.6%) 1 (2.8%) 1 (2.8%) 0.936 1 (16.7%) 2 (33.3%) 1 (16.7%) 1 (16.7%) 0 (0.0%) 1 (16.7%) 15 (40.5%) 6 (16.2%) 7 (18.9%) 8 (21.6%) 1 (2.7%) 0 (0.0%) 0.156 2 (22.2%) 7 (77.8%) 11 (15.1%) 62 (84.9%) 0.579 0 (0.0%) 9 (100.0%) 4 (5.5%) 69 (94.5%) 0.472 0 (0.0%) 9 (100.0%) 73 (100.0%) 0 (0.0%) 0.000 0 (0.0%) 9 (100.0%) 73 (100.0%) 0 (0.0%) 0.000 5 (55.6%) 4 (44.4%) 73 (100.0%) 0 (0.0%) 0.000 8 (88.9%) 1 (11.1%) 73 (100.0%) 0 (0.0%) 0.004 6 (66.7%) 3 (33.3%) 73 (100.0%) 0 (0.0%) 0.000 8 (88.9%) 1 (11.1%) 73 (100.0%) 0 (0.0%) 0.004 6 (66.7%) 3 (33.3%) 51 (75.0%) 17 (25.0%) 0.592 Table 6. Logistic Regression Analysis of Complication Late 95% C.I. for OR Variables B S.E. Wald p-value OR Lower Upper Duration of operation (min) -0.021 0.010 3.846 0.050 0.980 0.960 1.000 Stone dusting (1) 2.077 0.960 4.679 0.031 7.979 1.215 52.381 Constant 2.726 1.573 3.003 0.083 15.275 Table 7. Correlation Analysis Primary and Secondary Outcomes Corr. Coeff. (r) Stone Free r Stone Free Type of anesthesia Type of flexible uretero -scopy 1.000 - - p-value Complicati ons Late r p-value Size of laser fiber Stone dusting Pop cornlith o trips Dormia used .581** .248* -0.036 .229* .261* 0.000 0.030 0.757 0.046 0.022 -.237* -0.232 0.026 -.312** -0.005 0.032 0.135 0.818 0.004 0.966 Type of jj stent Duration of operation minutes Radiology follow up Size right Size left .316** .265* 0.005 0.020 0.072 -0.039 0.523 0.728 Right residual diameter Left residual diameter .349** .450** 0.002 0.000 .435** .701** .731** 0.000 0.000 0.000 -0.140 0.036 -0.064 -0.127 0.008 -0.146 0.209 0.756 0.577 0.273 0.960 0.350 ER Visits Comp. 1 Comp. 2 Comp. 3 Comp. 4 Plan 0.061 0.061 0.128 -0.068 0.187 0.598 0.598 0.266 0.557 0.104 0.557 -1.000** -1.000** -.645** -.316** -.555** -.316** 0.000 0.004 0.000 0.004 -0.068