Dr. Fazila Rajab

 Introduction The coronavirus disease-19 (COVID-19) is a highly contagious disease caused by a novel virus identified as severe acute respiratory syndrome coronavirus 2 (SARS CoV-2). To date there is no specific effective antiviral drug option against SARS CoV-2, yet. The pandemic has adversely affected the global healthcare system. Treatment options forMedical treatments applied against Covid-19 can be examined categorized into four categories: general treatments, coronavirus-specific treatments, antiviral treatments and other methods [1,2]. General treatments includes nutritional supplements, immune boostersystem enhancers, and some alternative medications in folk medicine [3]. All over the world against SARS CoV-2, Various treatment strategies based on the use of available drugs have been tried against SARS CoV-2 at global level, but an no effective treatment protocol has not been found. In addition, almost all antivirals available against SARS CoV-2 have been tested. Among the drugs that have been investigated for their effectiveness against SARS CoV-2, thereThere are many drugs, such as chlorokin/hydroxychloroquine, ribavirin, remdesievir, favipiravir or combinations of these drugs, which are found to be effective against SARS CoV-2 [4]. Although some reports studieswere initially reported that one or more of these drugs were effective against SARS CoV-2 in some countries, later some scientific studies reported that these drugs did not have the expected level of effectiveness against SARS CoV-2 [4,5]. Previous treatments targeting SARS-CoV and MERS-CoV may accelerate the development of the Covid-19 treatment due to their structurale and genomice similarities. Antiviral effective therapies include act by arresting viral replication stages and the inactivation or inhibition of the enzymes or steps involved in these stages. One of the most well-best characterized and conserved drug targets of coronaviruses is integrase, the main protease proteins. Inhibiting the activity of the Parent Protease Protein will block this enzyme would block viral replication, for which. pProtease inhibitors are used. drugs that can inhibit protease enzymes. One of the most important targets that can inhibit viral replication against SARS CoV-2 is the inactivation of the RNA-dependent RNA polymerase enzyme. Inactivation of this enzyme will prevents virus replication. Today, some of the available protease and RNA polymerase enzyme inhibitor drugs available are being redesigned to treatagainst SARS CoV-2 [6–9]. In cases where vaccines against SARS CoV-2 may be insufficient, the most important weapon of humanityhumanity's most important weapon wouldill be an effective antiviral drug. For this reason, it is an extremely important and indispensable need crucial to produce an effective antiviral drug against this highly contagious and deadly virus, which affects millions of people in a very short time all over the world and causes the death of hundreds of thousands of people. Small modifications to the inhibitory ligand can significantly affect the conformations of the molecules, changing induce conformational changes in the molecules by changing the binding modes and interactions of the proteinprotein's binding modes and interactions to the active site, and thus their activity. In this context, some compounds that inhibits viral RNA polymerases in the literature were scanned examined to find a scaffold, which would and will be active against Covid-19. The scaffold was determined to show the best activity against Covid-19. In order to design a newer, more active compound, vVarious modifications were made on to theis structure to design a newer, more active compound and to reach the target molecules. A and a target molecule that could be effective against Covid-19 has beenwas designed.