9/3/2019
Health and Food: Does a Healthy Diet Help Patients with Amyotrophic Lateral Sclerosis Disease?
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Health and Food: Does a Healthy Diet
Help Patients with Amyotrophic
Lateral Sclerosis Disease?
A recent study by the Amyotrophic Lateral Sclerosis Multicenter Cohort
Study of Oxidative Stress Study Group, published in the JAMA
Neurology, investigated the e ects of a diet consisting of fruits and
vegetables to improve the respiratory function and the quality of life of
patients with ALS
Anna DeFreitas, MD
Jul 25 · 3 min read
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Health and Food: Does a Healthy Diet Help Patients with Amyotrophic Lateral Sclerosis Disease?
Photo by Brooke Lark on Unsplash
Amyotrophic Lateral Sclerosis (ALS)
Amyotrophic Lateral Sclerosis (ALS) is a rare neurological disorder that affects the nerve
cells which control voluntary muscle movement, like walking, swallowing, and talking.
The ALS is a progressive disease that begins with muscle cramps, muscle weakness,
slurred and nasal speech, difficulty to swallowing and chewing, and eventually leads to
muscle atrophy, paralysis, and respiratory failure.
The average survival time for patients with ALS ranges from 20 to 48 months, but 10%
to 20% of patients survive longer than 10 years. According to the authors of the JAMA
Neurology study, there is a growing interest in the role nutrition and environmental
factors play in the development and progression of the disease.
Some previous studies showed that the risk to ALS increases with a diet rich on
carbohydrates, glutamate, and fat, and low intake of vitamins, fruits and vegetables. Risk
of ALS is correlated with body mass index (BMI), meaning obese persons have an
increased danger to develop the disease.
In order to study the relation of nutrition in the progression of ALS, the authors analyzed
302 patients in the United States, with average age about 63 years, and with a history of
ALS symptoms of 18 months or less. The researchers measured the amyotrophic lateral
sclerosis function and respiratory function, and found that higher intakes of antioxidants
and carotenes from vegetables were associated with higher ALS function and respiratory
function.
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Health and Food: Does a Healthy Diet Help Patients with Amyotrophic Lateral Sclerosis Disease?
Fruits and vegetables high in antioxidants and carotenes benefit ALS
patients
“Our results indicate that greater intakes of antioxidant nutrients and foods high in
carotenoids appear to be associated with better function at study entry,” the authors wrote.
The explanation to the connection of diet and ALS is that oxidative stress is associated
with the development and progression of ALS. Oxidative stress is an imbalance between
the production of free radicals and the ability of the body to block their harmful effects
through the production of antioxidants.
There is some evidence that food may increase or decrease oxidative stress. Foods high
in antioxidants are fiber from beans, vegetables, fruits, and grains. Food groups
considered potentially good are whole grains, milk, yogurt, fruits, legumes, eggs, fish,
soy foods, protein from nuts and seeds, beneficial oils (from fish, nuts, avocado, olives,
and dressing), deep yellow, orange, and dark green vegetables, potatoes, and tomatoes.
Foods rich in beta carotene are sweet potatoes, pumpkin, carrots, dark leafy greens, such
as kale and spinach, romaine lettuce, squash, cantaloupe, red and yellow peppers,
apricots, broccoli, among others.
The conclusion of the study is that nutritional care
of patients with amyotrophic lateral sclerosis should
include the promotion of foods high in antioxidants
and carotenes, including fruits and vegetables.
References
1. Nieves JW, Gennings C, Factor-Litvak P, et al. Association Between Dietary Intake and
Function in Amyotrophic Lateral Sclerosis. JAMA Neurol. 2016;73(12):-.
doi:10.1001/jamaneurol-. National Institute of Neurological Disorders and Stroke. Amyotrophic Lateral Sclerosis
(ALS) Fact Sheet. (2018, August 09). Retrieved from:
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Health and Food: Does a Healthy Diet Help Patients with Amyotrophic Lateral Sclerosis Disease?
https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/FactSheets/Amyotrophic-Lateral-Sclerosis-ALS-Fact-Sheet.
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