Ana Aleksic

2/10/2021 10 Alleged Benefits of Ox Bile Supplements + Side Effects - SelfHacked Evidence BasedThis post has 85 references 4.7/5 10 Alleged Benefits of Ox Bile Supplements + Side Effects Medically reviewed by Jonathan Ritter, PharmD, PhD (Pharmacology), Puya Yazdi, MD | Written by Ana Aleksic, MSc (Pharmacy) | Last updated: July 23, 2020 CONTENTS Bile is a vital uid the body makes to digest fats and absorb fat-soluble vitamins. Bile supplements can eliminate gallstones, help the body detox, and https://selfhacked.com/blog/bile-supplements/ 1/22 2/10/2021 10 Alleged Benefits of Ox Bile Supplements + Side Effects - SelfHacked improve liver and gut diseases. They come in a variety of forms, of which ox bile is the most common. Continue reading to learn about the function of bile and the health e ects of bile supplements. What is Bile? Digests Fats Bile is a complex, vital, and unique uid produced by the liver to aid in the digestion of fats in the small intestine. The components of bile are actually quite eclectic. It’s yellowgreen in color and composed of 95% water in which the following compounds are dissolved, such as [1, 2, 3]: Bile acids and salts Phospholipids, cholesterol, and steroid hormones Pigments and amino acids Electrolytes and vitamins Antioxidants like melatonin and glutathione Antibodies like IgA Heavy metals, drugs, and environmental toxins The liver secretes about 600 ml of bile every day, which amounts to almost 3 cups [4]. Removes Toxins Bile is the body’s main way of eliminating harmful fat-soluble substances like toxins, drugs, and heavy metals. It’s also the main pathway for eliminating excessive cholesterol from the body [1]. Helps You Absorb Nutrients Bile dissolves dietary fats so that they can be more easily broken down by lipases. Bile acids enable the digestion and absorption of fats and fat-soluble vitamins like A, D, E, and K in the gut. Bile also protects the gut from infection by stimulating the gut immune system [5, 6, 7]. Bile Production Signals from the Gallbladder https://selfhacked.com/blog/bile-supplements/ 2/22 2/10/2021 10 Alleged Benefits of Ox Bile Supplements + Side Effects - SelfHacked The liver constantly makes bile that’s transported to the gallbladder via bile ducts. The gallbladder, a small sac-like organ located below the liver, stores and concentrates bile. After food intake, the gallbladder delivers bile into the small intestine where it aids in the digestion of fats [8]. The main signal in the body for the gallbladder to contract and release bile is cholecystokinin. Others include secretin, gastrin, and somatostatin and the vagus nerve [4, 9]. Bile salts are resistant to strong digestive enzymes in the gut are mostly reabsorbed after they achieve their e ects. This way, the body recycles bile salts, which can be stored and used again [10]. Bile Acids & Bile Salts Bile acids are made in the liver from cholesterol [4]. The 2 main bile acids made in the liver are cholic acid and chenodeoxycholic acid. Gut bacteria can modify these into 2 slightly di erent bile acids (into deoxycholic acid and lithocholic acid), but the liver still makes most bile acids overall [4]. Transforming cholesterol into bile acids is a multistep process that involves many di erent liver enzymes. Many of these enzymes are part of cytochrome P450, the body’s key detox pathway [11]. These are the most important cytochrome P450 enzymes for bile production [12]: CYP7A1 CYP8B1 CYP27A1 Bile acids can a ect their own production in the body. If they increase too much, they stop their own production. If they’re not produced enough, low levels activate receptors that tell the body to make more bile. The most important one is called the bile acid receptor (FXR) [12]. The activity of these enzymes is also strictly controlled by hormone and drug levels in the body. Hormones, toxins, and drugs can activate certain receptors (so-called nuclear receptors, which include VDR) that a ect gene expression. By turning on key genes, they help lower blood lipids, cholesterol, and detox drugs and toxins [13, 14, 15]. https://selfhacked.com/blog/bile-supplements/ 3/22 2/10/2021 10 Alleged Benefits of Ox Bile Supplements + Side Effects - SelfHacked When bile acids are taken back to the liver and bound to the amino acids glycine or taurine when they become bile salts. An enzyme called n-acetyltransferase is crucial for this step known as conjugation [4]. If this enzyme is not working properly, free bile acids are released instead of bile salts. Bile acids are incapable of digesting fats. Only bile salts act as natural gut detergents – they have the power to emulsify, dissolve and digest fats in the gut [4]. Advertisement Get the Regimen of A Top Biohacker Preparing His Body to Fight Coronavirus Joe Cohen is well-known for his work as a successful entrepreneur in the health eld after he overcame his many health issues using a personalized regimen. Find out exactly which supplements he takes and what lifestyle changes Joe has made to maintain optimal health and prepare his body to ght o infections. Enter your email GET THE REGIMEN Advertisement Get the Regimen of A Top Biohacker Preparing His Body to Fight Coronavirus Joe Cohen is well-known for his work as a successful entrepreneur in the health eld after he overcame his many health issues using a personalized regimen. Find out exactly which supplements he takes and what lifestyle changes Joe has made to maintain optimal health and prepare his body to ght o infections. Enter your email GET THE REGIMEN https://selfhacked.com/blog/bile-supplements/ 4/22 2/10/2021 10 Alleged Benefits of Ox Bile Supplements + Side Effects - SelfHacked Function 1) Bile Salts Remove Excess Cholesterol Bile salts are crucial for maintaining balanced cholesterol levels in the body [16]. Producing bile acids from cholesterol is the key pathway for removing cholesterol from the body. About half of the total cholesterol produced in the body is used to make bile acids [17]. 2) Bile Eliminates Bilirubin From the Body Bile salts play a key role in the removal of bilirubin from the body [18]. Bilirubin is the main pigment in bile. It’s a waste product of hemoglobin breakdown and has harmful e ects in the body if accumulated. Bilirubin buildup in the body causes jaundice [19]. The liver takes bilirubin bound to proteins from the bloodstream and then modi es it to make it into a yellow water-soluble form. It then secretes this bilirubin into bile with bile salts. The gut microbiome then breaks down it down into its basic form (free bilirubin) that is darker in color and can nally be eliminated in the stool [4, 20]. 3) Bile Salts Digest Proteins and Starches Bile salts are essential for digesting proteins and starches. They help break down dietary proteins by enhancing the digestive activity of protease enzymes in the pancreas [21]. 4) Bile Salts Help Remove Toxins Bile salts help the bile remove toxic substances from the body [22]. This includes drugs, environmental pollutants, and heavy metals such as mercury, lead, silver, and cadmium [1]. Scientists are still debating exactly how bile salts are able to do this. Toxins can activate genes that help make bile and phase II detox enzymes. Once the bile is produced, toxins are modi ed and added to bile along with bile salts. They travel along the gut and can be eliminated through the stool [15]. https://selfhacked.com/blog/bile-supplements/ 5/22 2/10/2021 10 Alleged Benefits of Ox Bile Supplements + Side Effects - SelfHacked 5) Bile Salts Help Absorb Fat-Soluble Vitamins Without bile salts, fat-soluble vitamins (Vitamin A, D, E, and K) cannot be absorbed. Bile salts break down fats and the vitamins dissolved in it into small particles called “micelles”. This allows cells in the gut lining to transport them into the body [15]. And it’s not just that bile salts a ect vitamin absorption. Some fat-soluble vitamins themselves can have an e ect on the amount of bile the body makes. This way, vitamins regulate their own levels [23]. When the dietary intake of fat-soluble vitamins is high, Vitamin A and vitamin D can deactivate genes that make bile to reduce their own absorption and vice versa. Vitamin A and vitamin D have a strong e ect on the receptors that a ect bile gene expression (via RAR, RXR, and VDR). This prevents a buildup or de ciency of vitamins A, D, E, and K under normal conditions [23]. In fact, vitamin A may have speci c therapeutic potential. It can help the bile re-establish its own feedback loops if it was interrupted for any reason. For example, vitamin A may help in cases when the body stops re-absorbing bile salts from the gut, which is needed to recycle bile salts that are re-used [23]. 6) Bile Protects the Gut from Infections Bile protects the organism from gut infections by [1]: Making immunoglobulin A (IgA), the rst line of defense against harmful microbes Stimulating the gut immune system On the other hand, chronic in ammation reduces bile production in the body. Increased in ammatory substances ( IL-1 beta, IL-6, TNF-alpha, and nitric oxide) all reduce bile secretion, this way making the gut vulnerable to infections [1]. When Bile Flow Becomes Dysfunctional Dysfunctional bile ow reduces the digestion of fats, absorption of vitamins, and toxins detox in the small intestine [24]. This leads to a condition known as cholestasis, which means “blocked bile ow”. Dysfunctional bile ow causes [25]: https://selfhacked.com/blog/bile-supplements/ 6/22 2/10/2021 10 Alleged Benefits of Ox Bile Supplements + Side Effects - SelfHacked Fats to build up in the gut instead of being broken down, which causes indigestion, stomach pain, loss of appetite, and greasy or gray-colored stools Vitamin A, D, E, and K de ciencies A buildup of toxic substances such as bilirubin. Increased bilirubin causes jaundice – itchy yellow-colored skin and eyes. Bilirubin has to be eliminated via urine, coloring it light-brown. Bile acid buildup increases oxidative stress, which can damage the liver and may even increase the risk of cancer [12] Bile cholesterol buildup that forms gallstones in the gallbladder Gallstones cause in ammation not only of the gallbladder but also of the liver and pancreas. In such cases, the surgical removal of the gallbladder is recommended [26, 27]. Increased susceptibility to gut infections Bile production and ow can become dysfunctional due to various causes. Some conditions that worsen the ow of bile salts include chronic in ammation, liver diseases such as hepatitis or cirrhosis, cystic brosis, and diabetes [12]. Bile Supplements: What Are the Options? How They Work Under normal conditions, the gallbladder releases the stored bile into the small intestine in response to food. Bile, containing bile salts, initiates the breakdown and absorption of fats [8]. But under abnormal conditions caused by diseases of the pancreas, liver, or hormones, bile salts are not properly absorbed, leading to the increased accumulation of fats in the gut [28, 29]. Bile supplements (like ox bile, other animal biles, UDCA, TUDCA, or other bile acids) act to counter bile salts de ciency in the gut and may [30]: Break down and eliminate cholesterol gallstones [3]. Protect the gut from damage and infections [31, 3]. Protect the liver and restore natural bile acid production and bile ow [32]. Help absorb fats and fat-soluble vitamins, reducing symptoms of indigestion and greasy stools [33]. https://selfhacked.com/blog/bile-supplements/ 7/22 2/10/2021 10 Alleged Benefits of Ox Bile Supplements + Side Effects - SelfHacked Restore the cholesterol-lowering e ect of bile salts. Once supplemented bile is mixed up with gut contents, it’s removed with the stool. This loss of bile acids forces the liver to release more bile acids to compensate, transforming more cholesterol to bile acids. Reduce cholesterol production in the liver mediating the cholesterol-lowering e ects [34, 35, 36]. Reduce anxiety and promote sleep, due to their melatonin content [3]. Types of Supplements Various types of bile supplements are available, including all of the following: Ox bile Ox bile combined with various digestive enzymes (such as Pancrelipase, Pancreatic Protease, Pancreatic Amylase, Pancreatic Lipase, Papain, Bromelain) and/or Betaine HCl Ox bile combined with herbs such as dandelion root or artichoke Ox bile in combination with probiotics Ox bile combined with Taurine Puri ed bile salts such as TUDCA, ursodeoxycholic acid (Ursodiol or UDCA), cholic acid TCM bile supplements (see below) In most supplements, the dosage of ox bile varies between 100 – 500 mg. The content of pure bile acids in ox bile is about 40%. Some supplements may be puri ed to contain higher amounts [37]. In Traditional Chinese Medicine Ox bile and other animal bile supplements were an important part of Traditional Chinese Medicine (TCM) since ancient times. There was a wide assortment of animal biles for medicinal use, the total number adding up to 44, of which ox bile was perhaps the most important one [3]. The rst mention of bile in TCM dates back to scriptures from 500 BC that mention the use of ox and dog bile for therapeutic purposes. Biles mentioned in other TCM books are from: the common carp sh, goat, sheep, mouse, shark, wild boar, elephant, tiger, and even bile from pythons and venomous vipers [3]! https://selfhacked.com/blog/bile-supplements/ 8/22 2/10/2021 10 Alleged Benefits of Ox Bile Supplements + Side Effects - SelfHacked Interestingly, python bile was traditionally used to eliminate parasites and reduce gum in ammation and tooth cavities. Ox bile was used in combination with gentian root, other herbs, and honey to combat jaundice or used on the skin for hemorrhoids. A recent analysis showed that di erent animal biles have di erent components. Accordingly, speci c animal bile supplements are used for a variety of acute and chronic diseases in TCM [3]. Only pig, ox and bear biles are extensively used in China today. Health Benefits of Ox Bile Supplements 1) Eliminate Gallstones Bile supplements may reduce cholesterol gallstones in the gallbladder (cholelithiasis), potentially reducing the need for surgical removal of the gallbladder. In one clinical trial of 24 people, bile acids (UDCA up to 1,000 mg/day) reduced cholesterol in gallstones after one month [38]. Bile acids (UDCA) reduced gallstones in 6 people with hepatitis B after 3 – 20 months (daily dose of 8 – 11 mg/kg). It completely dissolved the stones in 5 people and reduced liver enzymes. They remained gallstone free for at least 2 years [39]. The primary bile acid chenodeoxycholic acid (0.75 – 4.5 g/day) eliminated gallstones in a trial of 7 women with 6 – 22 months. It also restored bile acid production in the liver [40, 41]. 2) Help Remove Toxic Substances From the Body Bile supplements assist in the removal of toxic substances from the body [42]. Toxins that enter the body via pollution, food, or medications, as well as those that build up in the body, are usually broken down by the liver. They are then combined with bile salts, secreted into the gut as bile, and removed through the stool. However, they lack bile salt production results in the accumulation of these toxins in the liver, which can trigger many chronic diseases [43, 44]. https://selfhacked.com/blog/bile-supplements/ 9/22 2/10/2021 10 Alleged Benefits of Ox Bile Supplements + Side Effects - SelfHacked Bile acids and toxins activate the same receptors in the body, which increase liver detox pathways. In a way, the body views all fat-soluble pollutants (and the majority of environmental pollutants and drugs are fat-soluble) as “toxic bile acids”, which triggers the detox process [45, 46]. Aside from bile supplements themselves, herbal supplements that activate this pathway (PXR activators) may also be useful for people with bile issues [46]. 3) May Help Clear Gut Infections and SIBO Impaired bile salts production creates favorable conditions for intestinal bacterial overgrowth. Bacterial toxins, known as endotoxins, can damage the gut. If the gut damage is severe enough and gut immunity low, the result is a leaky gut barrier that can cause bacteria to enter the bloodstream and cause a systemic infection. On the other hand, lack of bile salts can also cause small intestinal overgrowth (SIBO) [47]. Bile salts have antimicrobial activity and protect the body against harmful bacteria [48, 44]. Bile salt supplements may be especially useful for people with liver cirrhosis who are very susceptible to SIBO and bacterial infections [42]. In several studies of rats with liver damage, bile acids supplements reduced bacterial overgrowth and prevented the bacteria and their toxins from entering the blood [49, 50]. In mice, bile salt supplements could turn on genes that activate the defense system against harmful bacteria [51]. 4) May Help with Psoriasis Bacterial endotoxins might play a role in developing psoriasis. People with psoriasis have detectable levels of endotoxins in the blood, which can cause or worsen in ammation. Bile de ciency may be the underlying cause, as it allows endotoxin to enter the blood and reach the skin. People with psoriasis also often complain of gut and gallbladder problems [52+]. The buildup of toxins and in ammatory substances in the skin can cause red, itchy, and scaly skin patches in psoriasis. Bile acids can balance the gut microbiome, protect from bacterial gut endotoxins, and reduce in ammation [52+]. https://selfhacked.com/blog/bile-supplements/ 10/22 2/10/2021 10 Alleged Benefits of Ox Bile Supplements + Side Effects - SelfHacked In a large clinical trial of 800 patients with psoriasis, oral bile acid supplementation (dehydrocholic acid) resolved psoriasis symptoms in 79% of all cases after 1 – 8 weeks. It had even better results in people with acute psoriasis, clearing symptoms in 95% of the cases. Two years later, 58% of chronic psoriasis patients were also symptom-free, compared to only 6% of those on conventional treatment [52]. In bile-de cient rats, bile acid supplements caused helped blocked gut toxins from entering the blood and helped detox them from the body. Enhancing detox with bile salts may also be useful for viral infections, herpes, and clogged arteries in heart disease – all conditions in which bacterial toxins build up in the body [53]. 5) May Improve Liver Disease Bile supplements are used for a number of diseases including cystic brosis (a genetic disease) and chronic liver diseases such as primary biliary cirrhosis and non-alcoholic fatty liver disease. Cystic brosis is a genetic disease that a ects many organs of the body including the liver. It leads to an abnormal structure and function of the liver [54]. In one clinical study, the bile acid UDCA improved liver function, reduced liver enzymes, and reversed damage in people with cystic brosis. All participants were also supplementing with pancreatic enzymes and taurine [55]. Primary biliary cirrhosis is a chronic liver disease in which the bile ducts become dysfunctional. Immune system dysfunction has been linked to its development. Bile supplements may help reduce and reverse the symptoms and bile duct damage [56]. In one clinical trial, the bile acid UDCA (13 – 16 mg/kg/day) prevented the worsening, improved symptoms, and prolonged survival in people with primary biliary cirrhosis [57]. In one study, UDCA had even more striking bene ts when combined with sadenosylmethionine (SAM-e) in 19 people with this disease. The combination of prolonged remission, reduced elevated liver enzymes, bilirubin, and cholesterol [58]. Non-alcoholic fatty liver disease happens when the liver can’t break down fats, so fat builds up in the liver. It’s not caused by alcohol use and is most common in obese people. https://selfhacked.com/blog/bile-supplements/ 11/22 2/10/2021 10 Alleged Benefits of Ox Bile Supplements + Side Effects - SelfHacked People with this disease don’t have functional bile salts, which worsens in ammation and damage. Bile supplements may help, but more research is needed [59, 60]. 6) Help with Diarrhea and Fatty Stool Disrupted bile ow leads to fat buildup in the gut and stool, which causes diarrhea and stomach pain. This condition is known as steatorrhea. Several diseases are linked to it: gut diseases like Celiac and Crohn’s, cystic brosis, kidney, pancreas, and liver diseases. A diet high in hard-to-digest fats, bers, grains, and excessive drinking can also trigger it. Bile supplements can help make up for the lack of bile salts and reduce steatorrhea. A synthetic bile salt cholylsarcosine (2 g/meal) greatly improved fat absorption in the gut and reduced steatorrhea and diarrhea in a clinical trial of 4 people who had part of their bowel surgically removed (short bowel syndrome). In comparison, natural bile salts improved steatorrhea but worsened diarrhea [61]. Taurine, an amino acid that conjugates with bile acids in the bile, can also help the body make more bile salts. It’s needed to conjugate bile acids into bile salts, which is key for their digestive action [62, 63]. In one clinical trial, taurine (30 mg/kg/day) increased fat digestion and absorption in 22 children with cystic brosis over six months [64]. Taurine supplementation enhanced the activity of the key enzyme needed to convert cholesterol into bile acids (called 7α-hydroxylase) in animals. That’s why it’s also used for people with heart disease and high cholesterol levels [65]. 7) Help People without a Gallbladder People who have had their gallbladder removed su er from a de ciency of bile acids. Without the gallbladder, they are unable to control bile secretion to the intestines. This causes many digestive problems such as constipation, bloating, and diarrhea [66, 67]. The use of bile supplements can make up for the lack of bile, helps in the digestion of fats and absorption of fat-soluble vitamins. https://selfhacked.com/blog/bile-supplements/ 12/22 2/10/2021 10 Alleged Benefits of Ox Bile Supplements + Side Effects - SelfHacked The bile acid TUDCA reduced indigestion and improved symptoms in one trial of 203 people without a gallbladder [68]. 8) May Improve Eye Health The bile acid TUDCA improved eye health in mice and reduced the buildup of harmful free radicals. It may help prevent eye damage [69]. 9) May Enhance Weight Loss Bile acids may help prevent or reverse obesity by enhancing fat-burning. In animal studies, they helped with weight loss, improved insulin sensitivity and protected the heart. In fat cells, the bile acid chenodeoxycholic acid increased fat breakdown and energy use. This bile acid also reversed obesity in mice fed a high-fat diet by reducing food intake [70, 71]. In obese mice fed a high-fat diet, bile acids increased energy use, fat-burning, lowered glucose and improved the gut microbiome. They improved the overall metabolic pro le [72]. Another bile acid – deoxycholic acid – helps break down fat cells when injected directly under the skin into the fat tissue. Solutions of this bile acid are used in the USA and EU to improve the appearance of neck and chin fat. Several clinical trials proved its e ectiveness in improving the appearance of neck and chin fullness. It seems to be a welltolerated and safe option in plastic surgery [73]. 10) Help Heal Skin Burns and Infections In Traditional Chinese Medicine (TCM), animal bile is used to form an “arti cial skin” to dress and cover burns and wounds. Bile fats are isolated from bile have unique properties, which enables them to form a protective layer on the damaged skin. They also act as an antioxidant and anti-in ammatory due to the fat-soluble vitamins content while bile acids can kill bacteria [3]. As appealing or repelling as it may sound, bile has some great potential for repairing damaged skin. These studies are still limited to TCM, though, and more research is needed. Limitations and Caveats https://selfhacked.com/blog/bile-supplements/ 13/22 2/10/2021 10 Alleged Benefits of Ox Bile Supplements + Side Effects - SelfHacked Although the knowledge about the function of bile and various bile salts is growing, the information about bile supplements themselves is limited. The additional di culty is that there are big di erences between various bile acids as well as between di erent types of animal bile supplements. Some studies are limited to speci c bile salts or TCM observations. Proper, larger, clinical trials are needed, especially with popular ox bile supplements. Side Effects of Bile Supplements Considerations It’s important to note these side e ects really depend on the exact composition of bile salts and other ingredients in the supplement. Taking puri ed bile salts is not the same as taking mixed salts or various animal bile supplements. The side e ects also depend on your health condition. The side e ects in people with a surgically removed gallbladder or bowel part will not necessarily be the same as in someone with mild indigestion. Digestive Problems Bile supplements can cause digestive problems such as diarrhea, constipation, stomach pain, and vomiting. Although recommended for diarrhea, some natural bile salts may worsen diarrhea, as was the case with ox bile in people with a short bowel [61]. Chenodeoxycholic acid, present in some bile supplements, can too much water to be secreted into the gut, worsening diarrhea. It may even impair the gut barrier [74]. Gut Inflammation Some components in bile supplements may cause gut in ammation. Deoxycholic acid is a bile acid produced by gut bacteria and an ingredient in some supplements. In IBS, this acid is probably elevated, which worsens in ammation. In mice, deoxycholate supplementation triggered IBS and DNA/RNA damage [75]. Skin Inflammation (Rare) In one clinical trial of 24 people, direct exposure to bile salts caused skin itching and blisters [76]. https://selfhacked.com/blog/bile-supplements/ 14/22 2/10/2021 10 Alleged Benefits of Ox Bile Supplements + Side Effects - SelfHacked Oral bile supplements probably can’t cause skin in ammation, but skin application of the puri ed salts or their waste products found in the stool can. Puri ed digestive enzymes from the stool caused redness and irritation in a skin study. However, the mixture used also contained protein-degrading (proteolytic) and fat-degrading (lipolytic) enzymes that are not found in pure bile [77]. Also, this would be relevant perhaps only if applying bile supplements to the skin, which is not typical. Bile supplements that are applied to the skin are only occasionally used in China and specially modi ed and prepared. Possible Cancer Risk In a mice study, excessive and long-term exposure to bile salts caused colon cancer [78]. Some bile acids have been linked to a number of di erent cancers in animal studies, such as intestinal, stomach, pancreas, breast, and esophageal cancer [79, 80]. It was rst reported that bile acids may be carcinogenic in the 1930s [81]. Recent reports point to the cancer-promoting activity of bile acids [82, 83, 84]. Evidence suggests that high amounts of bile acids in the gastrointestinal tract might increase oxidative stress and DNA damage. High exposure to bile acids also happens in people with high dietary fat intake. However, the exact mechanism of how bile salts may promote cancer upon chronic exposure remains unknown [85]. A clear link between supplementing with bile salts and cancer is missing, though. A lot of the studies looked at high bile acid production caused by a high-fat diet in people, not at the use of bile supplements [82]. Bile acids can cause damage if they accumulate in the gut or liver. But a lot of the seen cancer-promoting e ects could be a result of factors that cause increased bile acid production in the rst place – such as a high-fat, unhealthy diet, or obesity – and not directly from bile salts themselves. More research is needed to shed light on this [12] Genetic Factors 1% – 2% of bile duct disorders in children are caused by defects in bile acid production [12]. https://selfhacked.com/blog/bile-supplements/ 15/22 2/10/2021 10 Alleged Benefits of Ox Bile Supplements + Side Effects - SelfHacked Some other genetic mutations in enzymes that make bile acids or aid in their activity can cause liver disease or fat-soluble vitamin de ciencies. Some examples include defects in the following genes [12]: CYP7A1 CYP7B1 AMACR VDR RAR and RXR FXR These variations may also a ect the e cacy and side e ects of bile supplements. Advertisement Avoid Illness By Using the Best Supplements For Your Body Ever try supplements that don’t seem to work? People respond di erently to diets and supplements because everyone has unique DNA. SelfDecode provides recommendations that are personalized based on YOUR genes to help you stay healthy and avoid infections from viruses like COVID-19! Analyze My Genes About the Author https://selfhacked.com/blog/bile-supplements/ 16/22 2/10/2021 10 Alleged Benefits of Ox Bile Supplements + Side Effects - SelfHacked Ana Aleksic MSC (PHARMACY) Ana received her MS in Pharmacy from the University of Belgrade. Ana has many years of experience in clinical research and health advising. She loves communicating science and empowering people to achieve their optimal health. Ana spent years working with patients who su er from various mental health issues and chronic health problems. She is a strong advocate of integrating scienti c knowledge and holistic medicine. https://selfhacked.com/blog/bile-supplements/ 17/22 2/10/2021 10 Alleged Benefits of Ox Bile Supplements + Side Effects - SelfHacked RATE THIS ARTICLE FDA Compliance The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure or prevent any illness or disease. Information is shared for educational purposes only. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition. https://selfhacked.com/blog/bile-supplements/ 18/22 2/10/2021 10 Alleged Benefits of Ox Bile Supplements + Side Effects - SelfHacked LOAD COMMENTS Leave a Reply Your email address will not be published. Required elds are marked * Comment Name * Email * Website Save my name, email, and website in this browser for the next time I comment. POST COMMENT This site uses Akismet to reduce spam. Learn how your comment data is processed. https://selfhacked.com/blog/bile-supplements/ 19/22 2/10/2021 10 Alleged Benefits of Ox Bile Supplements + Side Effects - SelfHacked JOE COHEN, CEO About Joe Joe Cohen won the genetic lottery of bad genes. As a kid, he su ered from in ammation, brain fog, fatigue, digestive problems, anxiety, depression, and other issues that were poorly understood in both conventional and alternative medicine. Read More Related Articles VIEW ALL 0 Blood Tests High Chloride Levels (Hyperchloremia) Symptoms & Causes 0 Genetics Genes that May A ect Uric Acid Levels Gut 4.3 15 12 IBD (Ulcerative Colitis and Crohn’s) Contributing Factors https://selfhacked.com/blog/bile-supplements/ 20/22 2/10/2021 10 Alleged Benefits of Ox Bile Supplements + Side Effects - SelfHacked (U ce at e Co t s a d C o s) Co t but g acto s SelfHacked Partner Solutions What do your genes tell you about your health? Align your health hacks with your genes for optimal health & cognitive function. CHECK OUT SELFDECODE NOW Our website services, content, and products are for informational purposes only. Sel acked LLC does not provide medical advice, diagnosis, or treatment. See additional information. SelfHacked © 2013 – 2021 All Rights Reserved Navigation Home Posts About Genetics Labs VIP Login Store https://selfhacked.com/blog/bile-supplements/ 21/22 2/10/2021 10 Alleged Benefits of Ox Bile Supplements + Side Effects - SelfHacked Careers Contact us Sitemap Login Our Policies Advertising Policy Genetics Labs Accessibility Editorial Policy Cookie Policy Corrections Policy Disclaimer Terms and Conditions Privacy Policy Login Contact Us- https://selfhacked.com/blog/bile-supplements/ 22/22